Factors influencing the use of an app for two-way risk communication concern what feedback would be given on adverse drug reaction reports and how safely these are stored and handled; what type of news, if any, would be provided through the app; other functions of the app; ease of use; the source (authority) behind the app; appropriate language and appeal of the app; and costs.

User characteristics (e.g. age, education, experience with apps) may moderate to what extent specific factors (e.g. functions, security) influence use of the app.

When designing or improving an app for two-way risk communication, pharmacovigilance experts, and app researchers and developers should consider the identified factors.