Table 1.
Group | No. of Subjects | % Male | Age at Tissue Collection, years Median [IQR] | Mean EF, % | Proportion on Medication
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---|---|---|---|---|---|---|---|---|---|---|---|
PDE3i | Non-PDEi Inotrope* | Digoxin | ACEi | Beta-blocker | Diuretic | Antiarrhythmic | |||||
Adult | |||||||||||
Nonfailing (LV) | 20 | 55 | 52 [15.5] | 59 | 0.00 | 0.65 | 0.00 | 0.00 | 0.20 | 0.10 | 0.00 |
Dilated cardiomyopathy | 38 | 74 | 47 [22.5] | 13 | 0.39 | 0.59 | 0.83 | 0.56 | 0.36 | 0.97 | 0.32 |
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Pediatric | |||||||||||
| |||||||||||
Nonfailing (LV) | 12 | 50 | 7.5 [7.9] | 54 | 0.00 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
Dilated cardiomyopathy | 33 | 36 | 3.1 [8.4] | 23 | 0.73 | 0.27 | 0.42 | 0.85 | 0.13 | 0.94 | 0.21 |
Nonfailing (RV) | 10 | 60 | 7.5 [9.7] | NA | 0.00 | 0.56 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
Single right ventricle | 18 | 67 | 5.6 [4.7] | NA | 0.61 | 0.13 | 0.53 | 0.71 | 0.00 | 1.00 | 0.07 |
ACEi, angiotensin-converting enzyme inhibitor; EF, ejection fraction; IQR, interquartile range; LV, left ventricle; NA, not available; PDEi, phosphodiesterase inhibitor; RV, right ventricle.
Non-PDEi inotropes include dopamine, dobutamine, epinephrine, and norepinephrine.