Table 3.
AC Expression (Mean (SD)) by Phosphodiesterase (PDE) 3i Treatment (Disease Versus Disease Treated With PDE3i)
| AC Isoform | Adult DCM | Adult DCM + PDE3i | Fold Change | Effect Size | P Value | Ped DCM | Ped DCM + PDE3i | Fold Change | Effect Size | P Value | Ped SRV | Ped SRV + PDE3i | Fold Change | Effect Size | P Value |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AC2 | 0.463 (0.215) |
0.368 (0.37) |
−1.260 | −0.291 | .137 | 2.407 (1.878) |
3.720 (2.625) |
1.545 | 0.254 | .177 | 2.593 (2.342) |
2.136 (2.036) |
−1.214 | −0.081 | .784 |
| AC3 | 0.774 (0.617) |
0.454 (0.372) |
−1.705 | −0.235 | .222 | 0.627 (0.352) |
0.843 (0.428) |
1.345 | 0.227 | .229 | 0.789 (0.812) |
1.243 (0.842) |
1.576 | 0.548 | .036* |
| AC4 | 1.020 (0.471) |
0.842 (0.611) |
−1.212 | −0.196 | .321 | 0.853 (0.406) |
0.877 (0.419) |
1.028 | 0.018 | .917 | 1.663 (0.803) |
1.688 (1.095) |
1.015 | −0.027 | .946 |
| AC5 | 2.066 (1.678) |
4.989 (3.618) |
2.415 | 0.468 | .043* | 1.074 (0.367) |
1.282 (0.497) |
1.194 | 0.227 | .229 | 2.234 (1.217) |
2.803 (1.810) |
1.255 | 0.19 | .468 |
| AC6 | 2.612 (2.045) |
5.175 (3.348) |
1.981 | 0.487 | .035* | 1.059 (0.397) |
1.656 (1.229) |
1.564 | 0.190 | .312 | 0.568 (0.534) |
0.432 (0.216) |
−1.315 | −0.024 | .947 |
| AC7 | 0.172 (0.063) |
0.117 (0.042) |
−1.468 | −0.438 | .029* | 0.965 (0.383) |
1.702 (0.839) |
1.764 | 0.413 | .013* | 0.702 (0.447) |
0.769 (0.443) |
1.095 | 0.160 | .515 |
| AC8 | 1.194 (0.646) |
1.025 (0.749) |
−1.165 | −0.103 | .607 | 0.94 (0.471) |
0.981 (0.520) |
1.044 | 0.036 | .842 | 1.378 (1.267) |
1.193 (0.651) |
−1.155 | 0 | 1.0 |
| AC9 | 1.007 (0.629) |
0.726 (0.463) |
−1.387 | −0.177 | .37 | 0.783 (0.264) |
0.927 (0.341) |
1.184 | 0.172 | .361 | 0.786 (0.252) |
1.319 (0.935) |
1.678 | 0.268 | .301 |