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. Author manuscript; available in PMC: 2017 Apr 8.
Published in final edited form as: J Card Fail. 2016 Jul 15;23(1):72–80. doi: 10.1016/j.cardfail.2016.07.429

Table 4.

PDE Expression (Mean (SD)) by Disease (NF Versus All Disease)

PDE Isoform Mean (SD)
Fold Change Effect Size P Value Mean (SD)
Fold Change Effect Size P Value Mean (SD)
Fold Change Effect Size P Value
Adult NF Adult DCM Ped NF LV Ped DCM Ped NF RV Ped SRV
PDE1A1 1.156
(0.562)		 1.173
(0.714)		   1.015 −0.102 .829  
PDE1C1 1.185
(0.830)		 0.828
(0.634)		 −1.432 −0.215 .191 1.195
(0.635)		 0.969
(0.408)		 −1.233 −0.177 .286   0.713
(0.26)		 1.308
(0.93)		   1.836   0.475 .032*
PDE3A1-1 1.08
(0.519)		 1.116
(0.645)		   1.033 −0.015 .928 1.149
(0.594)		 1.223
(0.534)		   1.064   0.064 .697   0.988
(0.224)		 2.267
(1.304)		   2.295   0.544 .004*
PDE3A1-2 1.21
(0.552)		 1.139
(0.629)		 −1.062 −0.018 .911 1.580
(1.521)		 1.464
(1.045)		 −1.079   0.030 .85     0.947
(0.45)		 1.573
(0.971)		   1.661 0.31 .068  
PDE3B 1.452
(1.105)		 2.279
(1.671)		   1.570   0.225 .142 1.165
(0.657)		 1.657
(0.754)		   1.422   0.281 .083   0.618
(0.191)		 1.522
(0.949)		   2.464   0.671 .001*
PDE4A3 1.305
(0.606)		 0.582
(0.507)		 −2.240 −0.332   .038* 0.992
(0.355)		 0.976
(0.5243)		 −1.017 −0.075 .656  
PDE4D3 1.202
(0.884)		 1.471
(0.873)		   1.224     0.1849 .247 1.076
(0.368)		 1.513
(0.975)		   1.406 0.12 .464   1.141
(0.568)		 1.404
(0.798)		   1.230   0.031 .436  
PDE4D5 1.161
(0.645)		 1.286
(0.575)		   1.108 0.08 .487 0.965
(0.304)		 0.957
(0.47)		 −1.009 −0.064 .714   0.682
(0.343)		 1.566
(1.009)		   2.296   0.618 .003*
PDE4D8 1.318
(0.804)		 0.636
(0.327)		 −2.064 −0.47   .002* 1.380
(1.091)		 0.479
(0.303)		 −2.880 −0.422 .007* 0.790
(0.354)		 1.661
(1.373)		   2.103   0.285 .062  
PDE4D9 1.149
(0.723)		 0.884
(0.366)		 −1.299 −0.133 .431 0.911
(0.388)		 0.322
(0.235)		 −2.828 −0.673 <.0001* 1.132
(0.724)		 1.405
(0.797)		   1.241   0.079 .436  
PDE5A 1.205
(0.582)		 4.978
(2.669)		   4.131 0.63   .001* 1.128
(0.515)		 2.902
(1.442)		   2.573 0.56   .0002* 1.001
(0.59)		 2.8
(1.168)		   2.797   0.752 <.0001*

Abbreviations as in Tables 1 and 2.

*

P < .05 is considered significant.