Table 5.
PDE Expression (Mean (SD)) by PDE3i Treatment (Disease Untreated Versus Disease Treated with PDE3i)
| PDE Isoform | Adult DCM | Adult DCM + PDE3i | Fold Change | Effect Size | P Value | Ped DCM | Ped DCM +PDE3i | Fold Change | Effect Size | P Value | Ped SRV | Ped SRV +PDE3i | Fold Change | Effect Size | P Value |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PDE1A1 | 1.811 (1.537) |
1.073 (0.543) |
−1.688 | −0.166 | .531 | ||||||||||
| PDE1C1 | 0.695 (0.503) |
1.205 (0.998) |
1.734 | 0.232 | .25 | 0.919 (0.45) |
1.062 (0.515) |
1.155 | 0.091 | .628 | 0.945 (0.385) |
1.271 (0.804) |
1.344 | 0.183 | .504 |
| PDE3A1-1 | 0.965 (0.485) |
1.322 (0.831) |
1.369 | 0.197 | .291 | 1.034 (0.538) |
1.368 (0.605) |
1.323 | 0.217 | .248 | 3.727 (2.432) |
1.660 (0.935) |
−2.245 | −0.45 | .07 |
| PDE3A1-2 | 1.122 (0.617) |
1.160 (0.665) |
1.076 | 0.057 | .762 | 1.092 (1.032) |
1.782 (1.464) |
1.632 | 0.276 | .157 | 1.182 (0.936) |
1.808 (0.96) |
1.530 | 0.407 | .115 |
| PDE3B | 2.018 (1.374) |
3.230 (2.617) |
1.532 | 0.2 | .277 | 1.299 (0.549) |
1.698 (0.724) |
1.307 | 0.236 | .218 | 2.145 (1.985) |
1.582 (1.021) |
−1.356 | −0.108 | .706 |
| PDE4A3 | 0.606 (0.522) |
0.556 (0.509) |
−1.090 | −0.121 | .551 | 0.878 (0.469) |
1.065 (0.589) |
1.214 | 0.141 | .453 | |||||
| PDE4D3 | 1.751 (1.49) |
1.699 (1.049) |
−1.031 | 0.057 | .771 | 1.324 (0.488) |
1.586 (1.107) |
1.198 | −0.009 | .978 | 1.173 (0.532) |
1.860 (1.334) |
1.586 | 0.219 | .385 |
| PDE4D5 | 1.150 (0.535) |
1.475 (0.603) |
1.283 | 0.277 | .258 | 0.639 (0.22) |
1.019 (0.455) |
1.594 | 0.383 | .046* | 1.859 (1.325) |
1.362 (0.726) |
−1.365 | −0.142 | .594 |
| PDE4D8 | 0.655 (0.354) |
0.616 (0.301) |
−1.063 | −0.071 | .731 | 0.289 (0.105) |
0.513 (0.303) |
1.772 | 0.336 | .078 | 2.408 (2.406) |
1.336 (0.672) |
−1.802 | −0.071 | .801 |
| PDE4D9 | 0.868 (0.442) |
0.908 (0.227) |
1.046 | 0.033 | .884 | 0.179 (0.07) |
0.317 (0.154) |
1.773 | 0.467 | .042* | 1.373 (0.869) |
1.427 (0.791) |
1.039 | 0.118 | .643 |
| PDE5A | 4.025 (2.379) |
6.202 (2.674) |
1.541 | 0.437 | .091 | 2.229 (0.936) |
2.990 (1.448) |
1.341 | 0.218 | .247 | 2.29 (0.44) |
2.896 (1.286) |
1.265 | 0.219 | .385 |