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. 2017 Apr 8;18:66. doi: 10.1186/s13059-017-1193-3

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Varying bin sizes for the synthetic normal and K nearest neighbor. Copy number ratios were calculated from the K nearest neighbor strategy for K = 5 at varying bins and compared to SynthEx Synthetic (composite synthetic normal) using: a the mean square successive difference at 100-kb non-overlapping bin sizes; b the Jaccard Index; c sensitivity; and d specificity using SNP array as the ground truth at 10 (red), 20 (blue), 50 (green), and 100 kb (purple)