Fig. 1.

The chromatin modification pathway was the most significantly altered. Bar plots show the predefined core cancer pathways’ [17] enrichment of the mutated genes at each clinical stage. The bar plot in red, blue, orange, and purple represents Stage I, Stage II, Stage III, and Stage IV, respectively. The Fisher’s exact test was performed to calculate the p value. The adjusted p value for each pathway was calculated using the Benjamini and Hochberg method. The logarithm transformation (base 10) was applied to the adjusted p value. Vertical red line represents the cut-off of the adjusted p value of 0.025