Table 1.
Patients and control subjects included in the study
| Patient | Age (years) | Characteristics |
|---|---|---|
| #1 | 67 | aComplementary treatment during radiochemotherapy for advanced carcinoma of hypopharynx. |
| bArterial hypertension under drug treatment and hyperglycemia under dietary treatment. | ||
| #2 | 74 | aComplementary treatment during radiochemotherapy for advanced carcinoma of base of tongue. |
| bChronic obstructive bronchitis (COB) under treatment with bronchodilator inhalers. | ||
| #3 | 63 | aComplementary treatment during radiochemotherapy for advanced carcinoma of supraglottis. |
| bHyperuricemia treated with allopurinol. Multiple sclerosis treated with baclofen. | ||
| #4 | 51 | aRadiation-induced necrosis of thyroid cartilage (radiotherapy was administered for carcinoma of glottis several years ago). |
| bTreatment with corticosteroids. | ||
| #5 | 78 | aChronic ulceration with calcaneous exposure and transplant failure. |
| bInsulin-dependent diabetes, arterial hypertension under drug treatment. Stroke 1 year ago. Duodenal ulcers. | ||
| #6 | 43 | Healthy subject. |
| #7 | 34 | Healthy subject. |
aReason for ozone therapy.
bConcomitant diseases or treatments (no changes were made in the medications during the period of Doppler evaluation). The study was planned with three ozone therapy sessions to evaluate the initial effects under the same conditions. Patient #1, #2 and #3 (cancer patients) were required to commence their scheduled radiochemotherapy after session #3; therefore, ethical considerations precluded delay in the cancer treatment. Ozone therapy was continued during the radiochemotherapy; however, radiotherapy of the cervical and carotid areas altered the subsequent Doppler evaluations. Patient #4 suffered from hemorrhage of the larynx. Ozone therapy was stopped after session #3 to enable the patient to undergo surgery. The usual complications associated with the surgical treatment of this radiation-induced necrosis were absent. Patient #5 who suffered from several vascular diseases was treated with systemic and local ozone therapy for a chronic wound. Patient #6 and #7 (healthy subjects recruited from among the hospital staff) also received 3 sessions of ozone therapy to evaluate the Doppler Effect. Further sessions were neither scheduled nor administered.