Table 5.

Multivariable hazard ratios for incident VTE events

	Any VTE	Unprovoked	Provoked	Cancer-related
Factor	HR (95% CI)	HR (95% CI)	HR (95% CI)	HR (95% CI)
Age ( per 10 years)	1.69 (1.48–1.92)*	1.58 (1.32–1.90)*	1.58 (1.36–1.84)*	1.74 (1.46–2.08)*
Female sex	0.78 (0.60–1.02)	0.42 (0.26–0.68)*	1.13 (0.76–1.67)	0.78 (0.50–1.22)
Obese (BMI ≥30)	1.88 (1.44–2.45)*	2.74 (1.75–4.30)*	1.15 (0.75–1.76)	1.97 (1.25–3.10)*
Diabetes	1.13 (0.75–0.70)	0.77 (0.35–1.71)	1.23 (0.66–2.28)	1.72 (0.93–3.19)
Aspirin use	1.09 (0.81–1.45)	0.77 (0.46–1.27)	1.18 (0.78–1.78)	0.88 (0.54–1.42)
Hypertension	1.03 (0.78–1.37)	1.14 (0.70–1.85)	1.07 (0.71–1.62)	0.82 (0.51–1.32)
Hypercholesterolemia	1.01 (0.76–1.34)	0.97 (0.62–1.53)	1.20 (0.81–1.78)	1.17 (0.74–1.84)

^*p<0.05.

Multivariable-adjusted Cox models were adjusted for age, sex and for variables that were significant in univariate models. The referent category is FHS participants without VTE events. Abbreviations: BMI= body mass index. CI= confidence interval; HR= hazard ratio