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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Basic Res Cardiol. 2016 Sep 19;111(6):62. doi: 10.1007/s00395-016-0583-0

Figure 2. Substances elaborated from the myocardium after prolonged ischemia exacerbate myocardial IS by acting on splenic leukocytes.

Figure 2

IHH from 40 minute ischemic myocardium (40-IHH) significantly exacerbated myocardial IS in 20′/60′ mice. However, 10-IHH had no effect on IS. The IS exacerbating effect of 40-IHH disappeared in splenectomized mice, but IS could be restored in splenectomized mice by SPAT. N = ≥5 mice/group. IHH: ischemic heart homogenate.