Table 2.
5XFAD behavior: 6 month – oral gavage study.
| Behavior | age (mon.) | wildtype – vehicle | wildtype - xamoterol | 5XFAD - vehicle | 5XFAD – xamoterol | Statistics |
|---|---|---|---|---|---|---|
| pre-dose Open Field (distance moved, cm) | 3.4 | 6232.6 ± 323.2 | 6179.9 ± 288.8 | 5767.4 ± 355.7 | 7131.3 ± 437.9 | one-way ANOVA NS |
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| pre-dose Y-Maze (% alternation) | 3.5 | 54.6 ± 3.5 | **57.4 ± 1.8 | *56.1 ± 2.3 | 55.2 ± 4.4 | one sample t-tests versus chance (50%); * p < .05, ** p < .01 |
|
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| Social Discrimination (discrimination ratio) | 5.4 | 0.034 ± 0.152 | 0.137 ± 0.098 | 0.270 ± 0.071 | 0.109 ± 0.132 | one-way ANOVA NS |
|
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| Open Field (distance moved, cm) | 5.5 | 7458.0 ± 559.5 | 6434.4 ± 397.7 | 7319.6 ± 553.9 | 7875.5 ± 815.0 | one-way ANOVA NS |
|
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| Y-Maze (% alternation) | 5.6 | 50.7 ± 3.7 | 56.4 ± 3.2 | ***64.3 ± 2.9 | 53.0 ± 4.2 | one sample t-tests versus chance (50%) *** p < .001 |
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| NOR (discrimination ratio) | 5.8 | 0.391 ± 0.091 | 0.446 ± 0.037 | 0.278 ± 0.086 | 0.551 ± 0.039 | one-way ANOVA F(3,36) = 2.794; p = .054; TREND |
|
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| Morris Water Maze (escape latency; sec) | 6.2 | two-way ANOVA | ||||
| day 1 | 58.2 ± 0.9 | 55.5 ± 1.9 | 57.9 ± 1.2 | 50.7 ± 3.2 | DAY: F(5,31) = 29.31 ***p < 0.001 |
|
| day 2 | 49.7 ± 4.4 | 47.4 ± 3.7 | 44.9 ± 4.0 | 45.1 ± 2.7 | GROUP: NS INTERACTION: NS |
|
| day 3 | 39.0 ± 3.7 | 44.9 ± 4.0 | 42.7 ± 4.5 | 30.3 ± 3.8 | ||
| day 4 | 40.9 ± 7.7 | 43.1 ± 4.3 | 41.7 ± 4.9 | 30.3 ± 4.0 | ||
| day 5 | 27.6 ± 8.1 | 35.0 ± 4.2 | 35.0 ± 4.9 | 30.5 ± 4.1 | ||
| day 6 | 25.9 ± 4.9 | 28.7 ± 4.6 | 34.8 ± 5.5 | 23.1 ± 4.1 | ||
| MWM - probe trial (target quadrant ratio) | 0.99 ± 0.20 | 1.06 ± 0.13 | 1.03 ± 0.19 | *1.43 ± 0.10 | one sample t-tests * ratio > 1.0; * p < .05 |
|