Table 3.
5XFAD behavior: 9 month – pump study.
| Behavior | age (mon.) | wildtype – vehicle | wildtype - xamoterol | 5XFAD - vehicle | 5XFAD – xamoterol | Statistics |
|---|---|---|---|---|---|---|
| pre-dose Open Field (distance moved, cm) | 3.1 | 6686.8 ± 279.1 | 6502.9 ± 176.4 | 6208.2 ± 719.8 | 6886.7 ± 374.3 | one-way ANOVA NS |
|
| ||||||
| pre-dose Y-Maze (% alternation) | 3.2 | 54.4 ± 2.7 | 53.8 ± 2.3 | *57.2 ± 2.7 | *57.8 ± 2.7 | one sample t-tests versus chance (50%); * p < .05 |
|
| ||||||
| Activity Chamber (distance moved, cm) | 8.0 | 4418.7 ± 564.8 | 5192.5 ± 385.9 | 5053.3 ± 571.0 | 4487.6 ± 300.7 | one-way ANOVA NS |
|
| ||||||
| Y-Maze (% alternation) | 8.1 | 53.6 ± 2.3 | *58.8 ± 3.0 | *57.8 ± 2.7 | *55.8 ± 2.2 | one sample t-tests versus chance (50%); * p < .05 |
|
| ||||||
| NOR (discrimination ratio) | 8.4 | 0.239 ± 0.052 | 0.158 ± 0.043 | 0.159 ± 0.066 | 0.305 ± 0.066 | one-way ANOVA NS |
|
| ||||||
| Morris Water Maze (escape latency; sec) | 8.8 | two-way ANOVA | ||||
| day 1 | 52.0 ± 3.6 | 36.7 ± 4.0 | 50.1 ± 3.3 | 51.6 ± 3.3 | DAY: F(3,30) = 44.84 ***p < 0.001 |
|
| day 2 | 29.9 ± 4.0 | 28.4 ± 6.8 | 40.3 ± 4.0 | 33.4 ± 4.9 | GROUP: F(3,30) = 2.612; p = .060; TREND | |
| day 3 | 36.1 ± 4.1 | 19.9 ± 5.6 | 29.0 ± 4.0 | 20.7 ± 3.4 | INTERACTION: F(9,30) = 1.982 p = .051; TREND |
|
| day 4 | 29.9 ± 4.5 | 16.6 ± 4.1 | 19.4 ± 2.8 | 17.0 ± 2.2 | ||
| MWM - probe trial (target quadrant ratio) | 2.60 ± 0.74 | *5.00 ± 1.46 | *6.07 ± 1.30 | *4.24 ± 0.94 | one sample t-tests * ratio > 1.0; * p < .05 |
|
|
| ||||||
| Elevated Plus Maze (% time open arms) | 9.1 | 9.9 ± 2.6 | 7.5 ± 1.4 | 18.2 ± 5.2 | 11.1 ± 2.9 | one-way ANOVA NS |
|
| ||||||
| Fear Conditioning | one-way ANOVA | |||||
| Acquisition (% freezing – trace) | 9.3 | 34.7 ± 7.6 | 57.5 ± 7.9 | 37.1 ± 7.9 | 42.5 ± 5.9 | NS |
| Cued Recall (% freezing – trace) | 9.3 | 30.3 ± 7.2 | 20.2 ± 5.8 | 29.4 ± 7.3 | 33.6 ± 4.3 | NS |
| Contextual Recall (% freezing min 2–5) | 9.3 | 27.1 ± 7.5 | 32.1 ± 9.1 | 19.8 ± 4.7 | 16.8 ± 3.1 | NS |