Table 5.
Time‐points | Estimated change ± SE and percent change | ||||||||
---|---|---|---|---|---|---|---|---|---|
0 | 6 months | 12 months | 0–6 months | % | 6–12 months | % | 0–12 months | % | |
Trabecular vBMD | 201.2 | 207.0 | 199.0 | 6.2 ± 5.4 | 3.1 | −8.5 ± 6.2 | −4.1 | −2.2 ± 8.1 | −1.1 |
Trabecular CSA | 544.0 | 680.0 | 627.0 | 136.1 ± 66.7 | 25.0 | −52.8 ± 75.8 | −7.8 | 83.3 ± 99.9 | 15.3 |
Cortical vBMD | 1,111.6 | 1,129.0 | 1,134.0 | 17.0 ± 25.1 | 1.5 | 5.7 ± 28.3 | 0.5 | 22.7 ± 35.4 | 2.0 |
Cortical CSA | 178.8 | 175.0 | 171.0 | −3.6 ± 7.2 | −2.0 | −4.0 ± 8.1 | −2.3 | −7.6 ± 10.2 | −4.2 |
Cortical BMC | 202.2 | 198.5 | 195.8 | −3.7 ± 7.4 | −1.8 | −2.7 ± 8.4 | −1.4 | −6.4 ± 10.5 | −3.2 |
CT | 3.99 | 4.01 | 3.97 | 0.03 ± 0.1 | 0.8 | −0.04 ± 0.11 | −1.0 | −0.02 ± 0.14 | −0.5 |
BSI | 60.8 | 60.0 | 58.0 | −1.0 ± 1.5 | −1.6 | −1.6 ± 1.7 | −2.7 | −2.6 ± 2.2 | −4.3 |
Zp | 1042.7 | 998.0 | 928.0 | −44.8 ± 46.9 | −4.3 | −70.1 ± 53.0 | −7.0 | −115.0 ± 66.3 | −11.0 |
SSI | 928.1 | 886.0 | 834.0 | −41.6 ± 37.0 | −4.5 | −52.2 ± 41.9 | −5.9 | −93.8 ± 52.3 | −10.1 |
Data are shown as adjusted means for the tibia length, estimated change ± SE, and percent change. BMC, bone mineral content (mg/mm); BSI, bone strength index (mg2/mm4); CT, cortical thickness (in mm); CSA, cross‐sectional area (mm2); vBMD, volumetric bone mineral density (mg/cm3); Zp, polar section modulus (mm3); SSI, strength strain index (mm3).