Table 2.
Top 50 most significantly upregulated genes in cardiomyocytes of female cardiomyocyte-specific GPER KO vs. WT mice
| Gene Symbol | Gene Description | Fold Change |
P Value |
|---|---|---|---|
| Myh7 | myosin, heavy polypeptide 7, cardiac muscle, beta | 6.87 | 0.00000 |
| 2810474O19Rik | RIKEN cDNA 2810474O19 gene | 3.32 | 0.00130 |
| Tmem 184c | transmembrane protein 184C | 2.73 | 0.00011 |
| Ndnf | neuron-derived neurotrophic factor | 2.72 | 0.00000 |
| Fgl2 | fibrinogen-like protein 2 | 2.63 | 0.00003 |
| Xist | inactive X specific transcripts | 2.62 | 0.00028 |
| Malat1 | metastasis associated lung adenocarcinoma transcript 1 | 2.46 | 0.01767 |
| Trpm7 | transient receptor potential cation channel, member M7 | 2.35 | 0.01411 |
| Acta1 | actin, alpha 1, skeletal muscle | 2.28 | 0.00318 |
| Nppa | natriuretic peptide type A | 2.26 | 0.00014 |
| Ankrd1 | ankyrin repeat domain 1 (cardiac muscle) | 2.22 | 0.00000 |
| Gck | glucokinase | 2.21 | 0.00001 |
| Phldb2 | pleckstrin homology-like domain, family B, member 2 | 2.17 | 0.00014 |
| Mybpc2 | myosin binding protein C, fast-type | 2.14 | 0.00000 |
| Zfp445 | zinc finger protein 445 | 2.11 | 0.00874 |
| Kdm7a | lysine (K)-specific demethylase 7A | 2.09 | 0.00391 |
| Dmxl2 | Dmx-like 2 | 2.06 | 0.00088 |
| Fam 198b | family with sequence similarity 198, member B | 2.06 | 0.00062 |
| Sorbs2 | sorbin and SH3 domain containing 2 | 2.05 | 0.01998 |
| Atrx | α thalassemia/mental retardation syndrome X-linked homolog | 2.04 | 0.02410 |
| Nbeal1 | neurobeachin like 1 | 2.04 | 0.01435 |
| Kif5b | kinesin family member 5B | 2.02 | 0.00769 |
| Gas5/Snord47 | growth arrest specific 5/small nucleolar RNA, C/D box 47 | 1.98 | 0.03187 |
| Rtn4 | reticulon 4 | 1.98 | 0.00000 |
| Rif1 | Rap 1 interacting factor 1 homolog (yeast) | 1.94 | 0.01003 |
| Akap9 | A kinase (PRKA) anchor protein (yotiao) 9 | 1.92 | 0.02423 |
| Tlr4 | toll-like receptor 4 | 1.92 | 0.00132 |
| Arid4b | AT rich interactive domain 4B (RBPl-like) | 1.91 | 0.00883 |
| Trove2 | TROVE domain family, member 2 | 1.90 | 0.00000 |
| Gdap10 | ganglioside-induced differentiation-associated-protein 10 | 1.90 | 0.02673 |
| Cfh | complement component factor h | 1.90 | 0.01042 |
| Ranbp2 | RAN binding protein 2 | 1.89 | 0.01033 |
| Kif5b | kinesin family member 5B | 1.87 | 0.01335 |
| Trip 11 | thyroid hormone receptor interactor 11 | 1.85 | 0.00204 |
| Cwf1912 | CWF19-like 2, cell cycle control (S. pombe) | 1.85 | 0.01437 |
| Acbd5 | acyl-Coenzyme A binding domain containing 5 | 1.84 | 0.02449 |
| H2-Aa | histocompatibility 2, class II antigen A, alpha | 1.84 | 0.00074 |
| Usp9x | ubiquitin specific peptidase 9, X chromosome | 1.81 | 0.00489 |
| Zfp367 | zinc finger protein 367 | 1.81 | 0.00794 |
| Ccnd2 | cyclin D2 | 1.80 | 0.00014 |
| Lin7c | lin-7 homolog C (C. elegans) | 1.80 | 0.04039 |
| Pcolce | procollagen C-endopeptidase enhancer protein | 1.79 | 0.00052 |
| Zfp62 | zinc finger protein 62 | 1.79 | 0.03314 |
| Phlda3 | pleckstrin homology-like domain, family A, member 3 | 1.79 | 0.00000 |
| Pnisr | PNN interacting serine/arginine-rich | 1.79 | 0.04485 |
| Lgals3 | lectin, galactose binding, soluble 3 | 1.79 | 0.00888 |
| Pde1c | phosphodiesterase 1C | 1.78 | 0.00067 |
| Cast | calpastatin | 1.78 | 0.01134 |
| Nabp1 | nucleic acid binding protein 1 | 1.78 | 0.00223 |
| Taok1 | TAO kinase 1 | 1.77 | 0.01954 |