Table 3.
Top 50 most significantly upregulated genes in cardiomyocytes of male cardiomyocyte-specific GPER KO vs. WT mice
| Gene Symbol | Gene Description | Fold Change |
P Value |
|---|---|---|---|
| Myh7 | myosin, heavy polypeptide 7, cardiac muscle, beta | 7.26 | 0.00000 |
| Ndnf | neuron-derived neurotrophic factor | 3.48 | 0.00000 |
| Lgals3 | lectin, galactose binding, soluble 3 | 3.15 | 0.00002 |
| Timp1 | tissue inhibitor of metalloproteinase 1 | 2.83 | 0.00000 |
| Fgl2 | fibrinogen-like protein 2 | 2.80 | 0.00001 |
| H2-Aa | histocompatibility 2, class II antigen A, alpha | 2.72 | 0.00000 |
| Nppa | natriuretic peptide type A | 2.65 | 0.00002 |
| Ctss | cathepsin S | 2.47 | 0.00016 |
| Col3a1 | collagen, type III, alpha 1 | 2.26 | 0.00555 |
| Cdkn1a | cyclin-dependent kinase inhibitor 1A (P21) | 2.23 | 0.00261 |
| Phlda3 | pleckstrin homology-like domain, family A, member 3 | 2.17 | 0.00000 |
| Lyz1 | lysozyme 1 | 2.17 | 0.00017 |
| H2-Eb1 | histocompatibility 2, class II antigen E beta | 2.16 | 0.00013 |
| Mybpc2 | myosin binding protein C, fast-type | 2.15 | 0.00000 |
| Lcn2 | lipocalin 2 | 2.12 | 0.00002 |
| Lyz2 | lysozyme 2 | 2.08 | 0.00023 |
| Cd74 | CD74 antigen | 2.07 | 0.00000 |
| Fcgr2b | Fc receptor, IgG, low affinity IIb | 2.05 | 0.00044 |
| Slc38a4 | solute carrier family 38, member 4 | 2.04 | 0.00189 |
| Tubb2a | tubulin, beta 2A class IIA | 2.03 | 0.00025 |
| Ccl 6 | chemokine (C-C motif) ligand 6 | 2.01 | 0.00224 |
| Nppb | natriuretic peptide type B | 2.00 | 0.00017 |
| Rtn4 | reticulon 4 | 1.99 | 0.00000 |
| Fam 198b | family with sequence similarity 198, member B | 1.99 | 0.00095 |
| Dpysl3 | dihydropyrimidinase-like 3 | 1.98 | 0.00000 |
| Pcolce | procollagen C-endopeptidase enhancer protein | 1.93 | 0.00017 |
| Tmem 176a | transmembrane protein 176A | 1.91 | 0.00001 |
| Hn 1 | hematological and neurological expressed sequence 1 | 1.88 | 0.00000 |
| Comtd 1 | catechol-O-methyltransferase domain containing 1 | 1.86 | 0.00000 |
| Socs3 | suppressor of cytokine signaling 3 | 1.83 | 0.02286 |
| Ctgf | connective tissue growth factor | 1.83 | 0.00093 |
| Tmem 176b | transmembrane protein 176B | 1.83 | 0.00000 |
| Ephx1 | epoxide hydrolase 1, microsomal | 1.81 | 0.00363 |
| Mthfd2 | methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase |
1.80 | 0.00097 |
| Stbd1 | starch binding domain 1 | 1.80 | 0.00000 |
| Ccl9 | chemokine (C-C motif) ligand 9 | 1.80 | 0.00011 |
| Ctsz | cathepsin Z | 1.79 | 0.00021 |
| Tyrobp | TYRO protein tyrosine kinase binding protein | 1.78 | 0.00025 |
| Apoe | apolipoprotein E | 1.77 | 0.00090 |
| Mt2 | metallothionein 2 | 1.77 | 0.00207 |
| C1qc | complement component 1, q subcomponent, C chain | 1.77 | 0.00104 |
| Acta1 | actin, alpha 1, skeletal muscle | 1.76 | 0.02983 |
| H2-Aa | histocompatibility 2, class II antigen A, alpha | 1.75 | 0.00240 |
| Slc38a1 | solute carrier family 38, member 1 | 1.75 | 0.00097 |
| 2610002J02Rik | RIKEN cDNA 2610002J02 gene | 1.75 | 0.00069 |
| H2-Ab1 | histocompatibility 2, class II antigen A, beta 1 | 1.73 | 0.00001 |
| Cpxm2 | carboxypeptidase X 2 (M14 family) | 1.71 | 0.04565 |
| Tspo | translocator protein | 1.70 | 0.00000 |
| Scd2 | stearoyl-Coenzyme A desaturase 2 | 1.70 | 0.00147 |
| Grk5 | G protein-coupled receptor kinase 5 | 1.70 | 0.00183 |