Table 4.
Top 50 most significantly downregulated genes in cardiomyocytes of cardiomyocyte-specific GPER female KO vs. WT mice
| Gene Symbol | Gene Description | Fold Change |
P Value |
|---|---|---|---|
| Amy1 | amylase 1, salivary | 0.37 | 0.00002 |
| Acot1 | acyl-CoA thioesterase 1 | 0.41 | 0.00031 |
| Il15 | interleukin 15 | 0.50 | 0.00523 |
| Ssbp2 | single-stranded DNA binding protein 2 | 0.51 | 0.00000 |
| Ano 10 | anoctamin 10 | 0.52 | 0.00000 |
| Dcakd | dephospho-CoA kinase domain containing | 0.53 | 0.00000 |
| Pfkfb1 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 | 0.53 | 0.00010 |
| 2310040G07Rik | RIKEN cDNA 2310040G07 gene | 0.54 | 0.00915 |
| 1700040L02Rik | RIKEN cDNA 1700040L02 gene | 0.54 | 0.00006 |
| Exoc2 | exocyst complex component 2 | 0.55 | 0.00000 |
| Dmd | dystrophin, muscular dystrophy | 0.56 | 0.07599 |
| Maob | monoamine oxidase B | 0.56 | 0.00000 |
| Ucp3 | uncoupling protein 3 (mitochondrial, proton carrier) | 0.56 | 0.00810 |
| Ctnna3 | catenin (cadherin associated protein), alpha 3 | 0.56 | 0.00001 |
| Aldob | aldolase B, fructose-bisphosphate | 0.57 | 0.00022 |
| Wif1 | Wnt inhibitory factor 1 | 0.58 | 0.01025 |
| Egflam | EGF-like, fibronectin type III and laminin G domains | 0.58 | 0.00031 |
| Acot2 | acyl-CoA thioesterase 2 | 0.60 | 0.00067 |
| G0s2 | G0/G1 switch gene 2 | 0.60 | 0.00614 |
| Acot1/Acot2 | acyl-CoA thioesterase 1 / acyl-CoA thioesterase 2 | 0.60 | 0.00105 |
| Immp2l | IMP2 inner mitochondrial membrane peptidase-like | 0.60 | 0.00002 |
| Sox4 | SRY (sex determining region Y)-box 4 | 0.61 | 0.02574 |
| Fdft1 | farnesyl diphosphate farnesyl transferase 1 | 0.61 | 0.00068 |
| Btg1 | B cell translocation gene 1, anti-proliferative | 0.61 | 0.00854 |
| Csrp2 | cysteine and glycine-rich protein 2 | 0.61 | 0.01669 |
| Kcnj3 | potassium inwardly-rectifying channel, subfamily J, member 3 | 0.61 | 0.00813 |
| Fbp2 | fructose bisphosphatase 2 | 0.64 | 0.00494 |
| Tm4sf1 | transmembrane 4 superfamily member 1 | 0.64 | 0.02878 |
| Apbb1 | amyloid beta precursor protein-binding, family B, member 1 | 0.65 | 0.00003 |
| Tesc | tescalcin | 0.65 | 0.00412 |
| Ttll1 | tubulin tyrosine ligase-like 1 | 0.65 | 0.00001 |
| Leprel4 | leprecan-like 4 | 0.65 | 0.00178 |
| Adhfe1 | alcohol dehydrogenase, iron containing, 1 | 0.65 | 0.00118 |
| Fah | fumarylacetoacetate hydrolase | 0.65 | 0.00130 |
| Entpd4 | ectonucleoside triphosphate diphosphohydrolase 4 | 0.66 | 0.04073 |
| Dpyd | dihydropyrimidine dehydrogenase | 0.66 | 0.00043 |
| Fbln1 | fibulin 1 | 0.66 | 0.01377 |
| Efnb3 | ephrin B3 | 0.66 | 0.00088 |
| Stom | stomatin | 0.66 | 0.02360 |
| Lipe | lipase, hormone sensitive | 0.67 | 0.00956 |
| Cdh5 | cadherin 5 | 0.67 | 0.04511 |
| Bcl2l11 | BCL2-like 11 (apoptosis facilitator) | 0.67 | 0.00215 |
| Adra1b | adrenergic receptor, alpha 1b | 0.67 | 0.00369 |
| Slc22a3 | solute carrier family 22 (organic cation transporter), member 3 | 0.67 | 0.00014 |
| AI464131 | expressed sequence AI464131 | 0.68 | 0.00596 |
| Fgf9 | fibroblast growth factor 9 | 0.68 | 0.00002 |
| Snrpn/Snurf | small nuclear ribonucleoprotein N upstream reading frame | 0.68 | 0.00089 |
| Smco4 | single-pass membrane protein with coiled-coil domains 4 | 0.68 | 0.00035 |
| Khdrbs3 | KH domain containing, RNA binding, signal transduction associated 3 | 0.68 | 0.00147 |
| Tmem 164 | transmembrane protein 164 | 0.69 | 0.02876 |