Table 5.
Top 50 most significantly downregulated genes in cardiomyocytes of male cardiomyocyte-specific GPER KO vs. WT mice
| Gene Symbol | Gene Description | Fold Change |
P Value |
|---|---|---|---|
| Dmd | dystrophin, muscular dystrophy | 0.21 | 0.00012 |
| Amy1 | amylase 1, salivary | 0.26 | 0.00000 |
| Gpr116 | G protein-coupled receptor 116 | 0.39 | 0.00162 |
| Pah | phenylalanine hydroxylase | 0.43 | 0.00832 |
| Aldob | aldolase B, fructose-bisphosphate | 0.44 | 0.00000 |
| Gpcpd1 | glycerophosphocholine phosphodiesterase GDE1 homolog | 0.47 | 0.00307 |
| Ppp2r3a | protein phosphatase 2, regulatory subunit B”, alpha | 0.49 | 0.00002 |
| Pfkfb1 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 | 0.50 | 0.00003 |
| Pde7a | phosphodiesterase 7A | 0.50 | 0.01219 |
| Fbln1 | fibulin 1 | 0.53 | 0.00075 |
| Gdap10 | ganglioside-induced differentiation-associated-protein 10 | 0.54 | 0.03215 |
| Iigp1 | interferon inducible GTPase 1 | 0.55 | 0.00188 |
| Ankrd32 | ankyrin repeat domain 32 | 0.55 | 0.03600 |
| Pdgfd | platelet-derived growth factor, D polypeptide | 0.56 | 0.00006 |
| 2310040G07Rik | RIKEN cDNA 2310040G07 gene | 0.56 | 0.01438 |
| Exoc2 | exocyst complex component 2 | 0.56 | 0.00000 |
| Luc712 | LUC7-like 2 (S. cerevisiae) | 0.57 | 0.03289 |
| Kcnj3 | potassium inwardly-rectifying channel, subfamily J, member 3 | 0.57 | 0.00332 |
| Fabp4 | fatty acid binding protein 4, adipocyte | 0.58 | 0.00018 |
| Ano 10 | anoctamin 10 | 0.58 | 0.00000 |
| Prrg 1 | proline rich Gla (G-carboxyglutamic acid) 1 | 0.58 | 0.00031 |
| Dpyd | dihydropyrimidine dehydrogenase | 0.58 | 0.00003 |
| Gpr22 | G protein-coupled receptor 22 | 0.58 | 0.00771 |
| Btnl9 | butyrophilin-like 9 | 0.59 | 0.00825 |
| Ddx3y | DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked | 0.59 | 0.02995 |
| Ets1 | E26 avian leukemia oncogene 1,5’ domain | 0.59 | 0.03764 |
| B230214O09Rik | RIKEN cDNA B23 0214O09 gene | 0.59 | 0.00219 |
| Cyr61 | cysteine rich protein 61 | 0.59 | 0.01297 |
| D7Ertd715e | DNA segment, Chr 7, ERATO Doi 715, expressed | 0.59 | 0.01290 |
| Wif1 | Wnt inhibitory factor 1 | 0.59 | 0.01242 |
| Cav2 | caveolin 2 | 0.60 | 0.04897 |
| Kcnd2 | potassium voltage-gated channel, Shal-related family, member 2 | 0.60 | 0.00045 |
| Il15 | interleukin 15 | 0.61 | 0.03395 |
| Gbp6 | guanylate binding protein 6 | 0.61 | 0.00999 |
| Etl4 | enhancer trap locus 4 | 0.61 | 0.00752 |
| Acot1 | acyl-CoA thioesterase 1 | 0.61 | 0.02195 |
| Ttll1 | tubulin tyrosine ligase-like 1 | 0.61 | 0.00000 |
| Eltd1 | EGF, latrophilin seven transmembrane domain containing 1 | 0.61 | 0.01848 |
| Btnl9 | butyrophilin-like 9 | 0.61 | 0.02541 |
| Dcakd | dephospho-CoA kinase domain containing | 0.62 | 0.00000 |
| Cyyr1 | cysteine and tyrosine-rich protein 1 | 0.62 | 0.02812 |
| Zbtb20 | zinc finger and BTB domain containing 20 | 0.62 | 0.04300 |
| Hnrnpa3 | heterogeneous nuclear ribonucleoprotein A3 | 0.63 | 0.02435 |
| Cyr61 | cysteine rich protein 61 | 0.63 | 0.01999 |
| Ube2b | ubiquitin-conjugating enzyme E2B | 0.63 | 0.03951 |
| Trdn | triadin | 0.63 | 0.00371 |
| 1810011O10Rik | RIKEN cDNA 1810011O10 gene | 0.64 | 0.01249 |
| Ssbp2 | single-stranded DNA binding protein 2 | 0.64 | 0.00017 |
| Tmod3 | tropomodulin 3 | 0.64 | 0.04622 |
| PggtIb | protein geranylgeranyltransferase type I, beta subunit | 0.64 | 0.03485 |