Table 6.

Summary of IPA in cardiomyocytes of female cardiomyocyte-specific GPER KO vs. WT mice

Top Canonical Pathways
Name	p-value	Overlap
Cardiomyocyte Differentiation via BMP Receptors	2.38E-03	10.0 % (2/20)
Maturity Onset Diabetes of Young (MODY) Signaling	2.62E-03	9.5% (2/21)
Epoxysqualene Biosynthesis	7.26E-03	50.0 % (1/2)
Antigen Presentation Pathway	8.00E-03	5.4% 2/37
Trehalose Degradation II (Trehalase)	1.09E-02	33.3% (1/3)
Top Diseases and Disorders
Name	p-value	#Molecules
Psychological Disorders	1.84E-02 - 1.30E-04	9
Neurological Disease	2.16E-02 - 1.94E-04	18
Skeletal and Muscular Disorders	1.84E-02 - 1.94E-04	15
Hematological Disease	2.16E-02 - 5.76E-04	8
Immunological Disease	2.16E-02 - 5.76E-04	7
Molecular and Cellular Functions
Name	p-value	#Molecules
Carbohydrate Metabolism	1.71E-02 - 3.90E-05	6
Molecular Transport	1.81E-02 - 3.90E-05	11
Small Molecule Biochemistry	1.83E-02 - 3.90E-05	14
Cell Death and Survival	2.16E-02 - 9.80E-05	27
Cellular Development	1.81E-02 - 1.12E-04	19
Physiological System Development and Function
Name	p-value	#Molecules
Embryonic Development	2.13E-02 - 9.80E-05	12
Hematological System Development and Function	1.81E-02 - 1.12E-04	8
Behavior	7.26E-03 - 1.30E-04	3
Nervous System Development and Function	1.81E-02 - 1.30E-04	15
Tissue Development	1.81E-02 - 1.30E-04	15
Cardiotoxicity
Name	p-value	#Molecules
Cardiac Arrhythmia	1.97E-01 - 9.33E-04	4
Cardiac Congestive Cardiac Failure	3.64E-03 - 3.64E-03	1
Heart Failure	2.36E-01 - 3.64E-03	2
Cardiac Transformation	7.26E-03 - 7.26E-03	1
Cardiac Hypertrophy	4.09E-01 - 8.95E-03	5