Table 7.

Summary of IP A in cardiomyocytes of male cardiomyocyte-specific GPER KO vs. WT mice

Top Canonical Pathways
Name	p-value	Overlap
Dendritic Cell Maturation	3.24E-04	3.4% 6/177
B Cell Development	6.61E-04	9.1% 3/33
Antigen Presentation Pathway	9.27E-04	8.1% 3/37
Autoimmune Thyroid Disease Signaling	1.86E-03	6.4 % 3/47
Graft-versus-Host Disease Signaling	1.98E-03	6.2 % 3/48
Top Diseases and Disorders
Name	p-value	#Molecules
Neurological Disease	7.99E-03 - 6.59E-10	42
Endocrine System Disorders	5.67E-03 - 4.82E-09	37
Gastrointestinal Disease	7.77E-03 - 4.82E-09	44
Metabolic Disease	5.19E-03 - 4.82E-09	28
Immunological Disease	7.99E-03 - 6.33E-09	32
Molecular and Cellular Functions
Name	p-value	#Molecules
Cell Death and Survival	7.99E-03 - 4.95E-07	49
Cellular Movement	7.52E-03 - 8.19E-07	31
Cell-To-Cell Signaling and Interaction	7.79E-03 - 3.12E-05	31
Cellular Assembly and Organization	7.99E-03 - 7.97E-05	30
Cell Morphology	7.79E-03 - 8.66E-05	29
Physiological System Development and Function
Name	p-value	#Molecules
Immune Cell Trafficking	7.52E-03 - 8.19E-07	21
Hematological System Development and Function	7.79E-03 - 1.29E-06	27
Endocrine System Development and Function	5.19E-03 - 1.45E-04	7
Cardiovascular System Development and Function	5.75E-03 - 1.59E-04	19
Organ Morphology	5.19E-03 - 1.59E-04	5
Cardiotoxicity
Name	p-value	#Molecules
Cardiac Hypertrophy	1.17E-01 - 2.08E-06	11
Congenital Heart Anomaly	1.42E-03 - 1.42E-03	2
Cardiac Infarction	3.43E-03 - 1.46E-03	5
Cardiac Necrosis/Cell Death	2.61E-01 - 1.83E-03	6
Cardiac Arrhythmia	2.68E-01 - 3.13E-03	5