Figure 2. HemoHIM decreased pro-inflammatory cytokines. (A) TNF-α, (B) IL-6, and (C) IL-1β. NC: Non-induced mice; CS+LPS: CS and LPS induced mice; ROF: roflumilast (10 mg/kg) and CS and LPS induced mice; H50: HemoHIM (50 mg/kg) and CS and LPS induced mice; H100 (100 mg/kg) and CS and LPS induced mice. The values are expressed as the means±SD. ^#Significantly different from the control mice, P<0.05; ^*Significantly different from the CS mice, P<0.05.