Figure 5. HemoHIM decreased the expression and activity of matrix metalloproteinase (MMP)-9 in lung tissue induced by CS and LPS exposure. (A) Representative figure of MMP-9 expression in lung tissue. (B) MMP-9 activity using zymography. NC: Non-induced mice; CS+LPS: CS and LPS induced mice; ROF: roflumilast (10 mg/kg) and CS and LPS induced mice; H50: HemoHIM (50 mg/kg) and CS and LPS induced mice; H100 (100 mg/kg) and CS and LPS induced mice. The values are expressed as the means±SD. ^#Significantly different from the control mice, P<0.05; ^*Significantly different from the CS mice, P < 0.05.