Table 3.
Characteristics | OR for NACC vs ACT* |
95%CI | p |
---|---|---|---|
Demographic and Clinical | |||
Older age at death (yrs) | 0.66 | (0.60, 0.82) | <0.001 |
Female | 1.40 | (1.08, 1.80) | 0.01 |
Non-white | 1.03 | (0.57, 1.88) | 0.92 |
College graduate | 1.77 | (1.38, 2.27) | <0.001 |
History of stroke | 0.92 | (0.65, 1.30) | 0.64 |
APOE ε4 allele | 1.31 | (0.99, 1.74) | 0.06 |
Demented at last visit | 2.13 | (1.35, 3.36) | 0.001 |
Clinical AD dementia | 1.68 | (1.07, 2.63) | 0.02 |
Pathologic | |||
Intermediate ADNC | 1.50 | (1.03, 2.20) | 0.03 |
High ADNC | 1.55 | (1.09, 2.19) | 0.01 |
Cortical LBD | 2.17 | (1.30, 3.63) | 0.003 |
Cortical microinfarcts | 0.35 | (0.27, 0.46) | <0.001 |
Gross infarcts | 1.01 | (0.76, 1.35) | 0.93 |
Severe atherosclerosis | 6.07 | (2.64, 13.97) | <0.001 |
Severe CAA | 3.17 | (1.98, 5.08) | <0.001 |
Hippocampal sclerosis | 0.69 | (0.45, 1.07) | 0.10 |
Primary age-related tauopathy | 1.72 | (1.21, 2.45) | 0.002 |
ACT, Adult Changes in Thought study; ADNC, Alzheimer’s disease neuropathologic change; CAA, cerebral amyloid angiopathy; LBD, Lewy body disease; NACC, National Alzheimer’s Coordinating Center
Based on a logistic regression model with ACT as the reference group; 498 NACC participants and 126 ACT participants excluded due to missing data; OR>1 if characteristic is more common in NACC compared to ACT