Table 3.

Multivariable regression model of NACC participants compared to ACT participants

Characteristics	OR for NACC vs ACT*	95%CI	p
Demographic and Clinical
Older age at death (yrs)	0.66	(0.60, 0.82)	<0.001
Female	1.40	(1.08, 1.80)	0.01
Non-white	1.03	(0.57, 1.88)	0.92
College graduate	1.77	(1.38, 2.27)	<0.001
History of stroke	0.92	(0.65, 1.30)	0.64
APOE ε4 allele	1.31	(0.99, 1.74)	0.06
Demented at last visit	2.13	(1.35, 3.36)	0.001
Clinical AD dementia	1.68	(1.07, 2.63)	0.02
Pathologic
Intermediate ADNC	1.50	(1.03, 2.20)	0.03
High ADNC	1.55	(1.09, 2.19)	0.01
Cortical LBD	2.17	(1.30, 3.63)	0.003
Cortical microinfarcts	0.35	(0.27, 0.46)	<0.001
Gross infarcts	1.01	(0.76, 1.35)	0.93
Severe atherosclerosis	6.07	(2.64, 13.97)	<0.001
Severe CAA	3.17	(1.98, 5.08)	<0.001
Hippocampal sclerosis	0.69	(0.45, 1.07)	0.10
Primary age-related tauopathy	1.72	(1.21, 2.45)	0.002

ACT, Adult Changes in Thought study; ADNC, Alzheimer’s disease neuropathologic change; CAA, cerebral amyloid angiopathy; LBD, Lewy body disease; NACC, National Alzheimer’s Coordinating Center

^*Based on a logistic regression model with ACT as the reference group; 498 NACC participants and 126 ACT participants excluded due to missing data; OR>1 if characteristic is more common in NACC compared to ACT