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. 2017 Apr 10;8:137. doi: 10.3389/fphar.2017.00137

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Copyright © 2017 Sorensen, Petersen, Timpani, Campelj, Cook, Trewin, Stojanovska, Stewart, Hayes and Rybalka.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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OXA penetrates the nuclear and mitochondrial fractions of TA muscle homogenates and increases succinate dehydrogenase (SDH) content. (A) OXA penetrated the nuclear and (B) mitochondrial fractions as quantified by Pt detection (n = 3–4). (C) SDH staining was significantly increased with OXA treatment but OXAB had no effect on this measure (n = 6–8). [Pt], Platinum concentration; SDH, SDH Succinate dehydrogenase; ppm, parts per million. Significance: ^*p = <0.05, ^**p = <0.005, ^***p = <0.0005.