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. 2017 Apr 10;8:137. doi: 10.3389/fphar.2017.00137

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Copyright © 2017 Sorensen, Petersen, Timpani, Campelj, Cook, Trewin, Stojanovska, Stewart, Hayes and Rybalka.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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BGP-15 protects against OXA-induced mitochondrial superoxide production and fiber diameter loss and improves mitochondrial viability in FDB fibers. OXA treatment induced (A) A 4-fold increase in mitochondrial density, with OXAB protecting against this increase. (B) OXAB protected against a 25% increase in MitoSOX fluorescence induced by OXA treatment. (C) OXA treatment reduced mitochondrial viability while OXAB treatment protected against the effects of OXA and improved viability 4-fold from VEH. Representative images of MitoSOX and MitoTracker stained FDB fibers (D,E). OXA treatment also induced a (F) 25% reduction in FDB Fiber diameter with OXAB protecting against this reduction. FDB, Flexor Digitorum Longus; Mito, Mitochondria; SOX, Superoxide. Significance: ^*p < 0.05, ^**p < 0.005, ^***p < 0.0005, ^****p < 0.0001. Trend: ^#p = 0.073, ^##p = 0.077. n = 4–6.