Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Apr 10;8:58. doi: 10.3389/fendo.2017.00058

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2017 Londraville, Prokop, Duff, Liu and Tuttle.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Modeling the 2xLEP–2xLEPR interaction. (A) Each of the top motifs for leptin (LEP) and leptin receptor (LEPR) are colored in respective color coding. LEP: motif 1, red; motif 2, blue. LEPR: motif 1, green; motif 2 and 4, magenta; motif 3, yellow; motif 5–7, cyan. (B) Magnified view of the Ig-like and LBD of LEPR showing the 2–2 interaction model based on vertebrate evolution. (C) Model of endogenous dimerized LEPR being activated by LEP binding.