TABLE 1.

SHIV89.6P titrations in neonatal and older rhesus monkeys

Route of inoculation	Animal	Age	Dilution	Systemic infection present	Peak viral RNA load at week 2 (RNA copies/ml)	CD4+ T cells (cells/μl)a
						at week 2	at week 4
Oral	RGt-6	1 day	1	Yes	110,750	1,240	397
	RHt-6	1 day	1:10	Yes	5,094,275	82	115
	RJv-6	1 day	1:20	Yes	15,036,775	2,880	150
	RJu-6	3 days	1:20	Yes	1,237,798	0	0
	RUz-6	2 days	1:40b	Yes	164,852	NDc	63
	RCu-6	1 day	1:100	No	<200	3,726	2,435
	RZt-6	1 day	1:1,000	No	<50	NDc	NDc
	RSt-7	11 months	1:6	Yes	363,726,500	27	42
	RAu-7	11 months	1:10	Yes	23,319,530	1,489	1,176
	RSs-7	12 months	1:100	Yes	27,688,625	68	66
	RGn-7	16 months	1:1,000	Yes	1,922,178	180	110
	REu-7	18 months	1:3,000	Yes	14,342,610	382	578
	RAy-7	18 months	1:6,000	Yes	8,824,345	1,058	1,323
	RPj-7	23 months	1:6,000	Yes	12,564,025	562	483
	RRd-7	16 months	1:10,000	No	<50	3,421	3,504
Intravenous	RZv-6	1 day	1:2,000	Yes	44,761,565	14	NDc
	RVv-6	1 day	1:20,000	Yes	52,827,105	23	14
	RWz-6	2 days	1:200,000	Yes	25,133,855	54	NDc
	RTe-7	1 day	1:2,000,000	Yes	484,813	110	0

^aThe absolute number of CD4⁺ T cells in naive infants at week 2 was 3,025; at week 3, 3155; and at week 8, 2,585 (8).

^bThe ratio of the minimal oral dose (1:40) to the assumed minimal i.v. dose (1:2 × 10⁶) in neonates was at least 50,000.

^cND, not determined.