Table 1.
Transcription factors of Helicobacter pylori 26695.
| Gene | Protein/Reference sequence | Functions | Reference |
|---|---|---|---|
| rpoD (hp0088) | RpoD, σ80/NP_206888.1 | Vegetative sigma factor, transcription of housekeeping genes | Tomb et al., 1997; Beier et al., 1998 |
| rpoN (hp0714) | RpoN, σ54/NP_207508.1 | Alternative sigma factor, expression of class II flagellar genes, stress and virulence | Josenhans et al., 2002; Niehus et al., 2004; Sun et al., 2013 |
| fliA (hp1032) | FliA, σ28/NP_207822.1 | Alternative sigma factor, expression of class III flagellar genes, stress and virulence | Josenhans et al., 2002; Niehus et al., 2004; Baidya et al., 2015 |
| hrcA (hp0111) | HrcA/NP_206911.1 | Involved in heat shock, stress response and motility | Spohn et al., 2004; Roncarati et al., 2007, 2014 |
| arsR (hp0166) | ArsR/NP_206965.1 | Acid adaptation, acetone metabolism, oxidative stress response, quorum sensing, and biofilm formation | Pflock et al., 2005, 2006; Loh et al., 2010; Servetas et al., 2016 |
| hp0222 | HP0222/NP_207020.1 | Possibly involved in acid response and/or bacterium-epithelial cell contact | Ang et al., 2001; Kim et al., 2004; Popescu et al., 2005 |
| hp0564 | HP0564/NP_207359.2 | Paralog of HP0222; unknown function | Borin and Krezel, 2008 |
| flgR (hp0703) | FlgR/NP_207497.1 | RpoN-dependent master regulator of class II flagellar genes | Spohn and Scarlato, 1999b; Brahmachary et al., 2004 |
| hup (hp0835) | HU/NP_207628.1 | Acid stress response, DNA protection from oxidative stress, involved in mouse colonization | Almarza et al., 2015; Wang and Maier, 2015 |
| hp1021 | HP1021/NP_207811.1 | Chromosomal replication regulator, acetone metabolism and growth | Beier and Frank, 2000; Pflock et al., 2007a; Donczew et al., 2015 |
| hspR (hp1025) | HspR/NP_207815.1 | Heat shock, acidic/osmotic stress response, and motility | Spohn and Scarlato, 1999a,b; Spohn et al., 2002, 2004; Roncarati et al., 2007 |
| fur (hp1027) | Fur/NP_207817.1 | Pleiotropic regulator involved in acid adaptation, metal homeostasis and Mongolian gerbil/mouse colonization | Bijlsma et al., 2002; Harris et al., 2002; van Vliet et al., 2003; Bury-Mone et al., 2004; Danielli et al., 2006; Gancz et al., 2006 |
| hsrA (hp1043) | HsrA/NP_207833.1 | Cell viability, oxidative stress, virulence, response to metronidazole | Olekhnovich et al., 2013, 2014; Vannini et al., 2016 |
| cheY (hp1067) | CheY/NP_207858.1 | Chemotaxis, motility, Mongolian gerbil/mouse colonization | Beier et al., 1997; Foynes et al., 2000; McGee et al., 2005; Terry et al., 2005 |
| nikR (hp1338) | NikR/NP_208130.1 | Nickel-response pleiotropic regulator, metal (copper, iron, and nickel) homeostasis, acid adaptation, iron uptake/storage, motility, chemotaxis, stress response, and mouse colonization | Contreras et al., 2003; Bury-Mone et al., 2004; Ernst et al., 2005b; Muller et al., 2011 |
| crdR (hp1365) | CrdR/NP_208157.1 | Copper resistance, survival under nitrosative stress, and mouse colonization | Panthel et al., 2003; Waidner et al., 2005; Hung et al., 2015 |