FIG. 1.

End-point anti-Env antibody titers in plasma against 89.6 gp140 were measured during the course of immunizations. (A) Data for two animals immunized with rAd5 encoding SIVmac239 Gag-Pol and HIV89.6P Env at 0, 8, and 26 weeks. rAd5 SIVmac239 and HIV89.6P Env were each administered at a dose of 10¹² particle units. (B) Data for two animals immunized with DNA plasmids at 0, 4, and 8 weeks and boosted with rAd5 at week 26. DNA plasmids encoded SIVmac239 Gag-Pol-Nef and HIV89.6P Env. Each plasmid was administered at a dose of 4.5 mg; the rAd5 constructs were administered as described above.