Table 5.
Multivariate analysis of prognostic factors for recurrence-free survival and overall survival in model with all 309 patients and 156 patients with positive F-18 fluorodexoyglucose uptake
| Variables |
Model with all patients |
Model with patients with positive FDG uptake |
||
| P value | HR (95%CI) | P value | HR (95%CI) | |
| RFS | ||||
| Age | 0.461 | 1.38 (0.58-3.28) | 0.228 | 1.69 (0.72-3.96) |
| Location | ||||
| Body | 1.00 | 1.00 | ||
| Fundus | 0.543 | 0.50 (0.05-4.78) | 0.634 | 0.58 (0.06-5.32) |
| Antrum | 0.276 | 0.64 (0.29-1.42) | 0.695 | 0.86 (0.41-1.82) |
| Multiple | 0.037 | 6.06 (1.36-26.92) | 0.034 | 5.19 (1.13-23.76) |
| T stage | ||||
| T1 | 1.00 | 1.00 | ||
| T2 | 0.342 | 1.81 (0.53-6.19) | 0.250 | 2.05 (0.60-6.99) |
| T3 | 0.200 | 2.31 (0.64-8.29) | 0.096 | 3.01 (0.82-10.97) |
| T4 | 0.020 | 4.99 (1.29-19.38) | 0.014 | 5.50 (1.42-21.31) |
| Lymph node metastasis | 0.037 | 2.96 (1.07-8.21) | 0.004 | 4.50 (1.61-12.54) |
| Tumor size | 0.661 | 1.27 (0.43-3.75) | 0.594 | 1.34 (0.46-3.95) |
| Tumor involvement of resection margin | 0.035 | 4.32 (1.11-16.81) | 0.023 | 4.94 (1.24-19.62) |
| White blood cell | 0.150 | 1.96 (0.78-4.92) | 0.053 | 2.37 (0.99-5.67) |
| Hemoglobin | 0.652 | 1.24 (0.49-3.11) | 0.955 | 0.97 (0.38-2.50) |
| NLR | 0.611 | 1.25 (0.53-2.90) | 0.607 | 1.24 (0.54-2.86) |
| PLR | 0.563 | 1.30 (0.53-3.18) | 0.197 | 1.78 (0.74-4.27) |
| Albumin | 0.060 | 0.42 (0.17-1.04) | 0.021 | 0.34 (0.14-0.85) |
| CRP | 0.173 | 1.88 (0.76-4.68) | 0.181 | 1.85 (0.75-4.55) |
| FDG uptake | 0.058 | 2.72 (0.97-7.65) | ||
| Tmax | 0.215 | 1.33 (0.70-2.39) | ||
| BM SUV | 0.945 | 0.94 (0.38-2.33) | 0.597 | 0.80 (0.34-1.86) |
| BLR | 0.001 | 6.42 (2.07-19.84) | 0.005 | 7.67 (2.44-24.12) |
| OS | ||||
| T stage | ||||
| T1 | 1.00 | 1.00 | ||
| T2 | 0.994 | 1.01 (0.13-8.41) | 0.965 | 1.93 (0.29-13.05) |
| T3 | 0.537 | 1.78 (0.28-11.15) | 0.500 | 1.93 (0.29-13.05) |
| T4 | 0.002 | 5.33 (1.88-15.14) | < 0.001 | 6.15 (2.18-17.34) |
| Lymph node metastasis | 0.016 | 5.08 (1.36-18.94) | 0.092 | 3.40 (0.82-14.11) |
| Tumor size | 0.243 | 3.62 (0.42-31.35) | 0.242 | 3.77 (0.41-34.80) |
| Tumor involvement of resection margin | 0.194 | 3.16 (0.56-17.93) | 0.209 | 3.13 (0.53-18.54) |
| Hemoglobin | 0.026 | 0.32 (0.11-0.87) | 0.463 | 0.46 (0.14-1.57) |
| PLR | 0.741 | 0.82 (0.25-2.66) | 0.896 | 0.92 (0.29-2.99) |
| Albumin | 0.759 | 0.84 (0.27-2.61) | 0.675 | 0.78 (0.24-2.52) |
| FDG uptake | 0.197 | 4.29 (0.47-39.12) | ||
| Tmax | 0.059 | 2.89 (0.96-8.72) | ||
| BLR | 0.025 | 10.39 (1.34-80.33) | 0.022 | 10.87 (1.42-83.31) |
FDG: F-18 fluorodexoyglucose; RFS: Recurrence-free survival; NLR: Neutrophil-to-lymphocyte ratio; PLR: Platelet-to-lymphocyte ratio; CRP: C-reactive protein; PET/CT: Positron emission tomography/computed tomography; BM: Bone marrow; BLR: BM-to-liver uptake ratio.