TABLE 2.
Correlation of common peptide-specific T-cell responses with shared MHC class I alleles
| Peptide or shared MHC class I allele | T-cell response or allele detection for macaque no:
|
|||||
|---|---|---|---|---|---|---|
| 4241 | 4247 | 4295 | 4296 | 4664 | 4293 | |
| Peptide | ||||||
| KP9 | ×a | × | × | × | × | |
| YP8 | × | × | ||||
| KW9 | × | × | ||||
| Allele | ||||||
| Mane-A*10b | + (12) | + (2)c | + (6) | + (14) | + (6) | |
| Mane-A*16 | + (12) | |||||
| Mane-A*11 | + (57) | |||||
| Mane-A*12 | + (10) | |||||
| Mane-A*14 | + (2) | + (2) | ||||
| Mane-B*10 | + (7) | + (6) | ||||
| Mane-B*11 | + (5) | |||||
| Mane-B*12 | + (4) | + (3) | ||||
| Mane-B*22 | + (2) | |||||
| Mane-B*13 | + (9) | + (3) | ||||
| Mane-B*18 | + (7) | + (10) | ||||
a
An × indicates the detection of a T-cell response by ELISpot of >50 antigen-specific IFN-γ spot-forming cells/106 PBMC to the epitopes listed.
b
MHC class I alleles possessing <5 nucleotide differences are shown grouped together (see the text).
c
A plus sign indicates detection of the allele, with the number of clones derived from each macaque shown in parentheses.