FIG. 5.
Adult soleus (SOL) D2 activity, gene expression and skeletal muscle function of Cre-MYF5 and MYF5-D2KO mice. (A) D2 activity of adult SOL muscle (n = 5). (B) Dio2 and selected triiodothyronine (T3)-responsive genes mRNA levels in SOL (n = 9–11). (C) Exercise time and maximum speed (Smax) achieved on the treadmill maximal exercise test. (D) Maximal force (100 Hz; Fmax) and twitch force (1 Hz) of electrically stimulated plantar flexors (e.g., soleus and gastrocnemius muscles) normalized by body weight. Values are the mean ± SEM. *p ≤ 0.05; **p ≤ 0.01 vs. Cre-MYF5.