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Potential role of exosomes containing Ebola VP40 in viral persistence. Infected cells in immune privileged sites (i.e., ocular fluid) could release exosomes containing viral proteins such as VP40. These exosomes may then travel to distant areas such as lymph nodes, where they may induce apoptosis in immune and T cell populations. Increased cell death in surveilling immune cells could allow for increased viral replication and persistence in local compartments.
