Table 1. Syk-regulated genes in Mincle-expressing RBL-2H3 cells.
| Gene | Description | Fold change | P value |
|---|---|---|---|
| Nr4a3 | nuclear receptor subfamily 4, group A, member 3 | 30.54 | 0.0001 |
| Il3 | Interleukin-3 | 26.37 | 0.0005 |
| Ccl1 | CCl1 | 22.62 | 0.0002 |
| Il31 | Interleukin-31 | 16.62 | 0.0018 |
| Il13 | Interleukin-13 | 14.29 | 0.003 |
| Egr3 | early growth response 3 | 12.84 | 0.0001 |
| Il4 | Interleukin-4 | 7.95 | <0.0001 |
| Ccl7 | CCl7 | 7.64 | 0.0022 |
| Klrb1c | killer cell lectin-like receptor subfamily B member 1C | 6.23 | 0.0144 |
| Egr1 | early growth response 1 | 5.66 | 0.0002 |
| Egr2 | early growth response 2 | 5.47 | 0.0007 |
| Gpr183 | G protein-coupled receptor 183 | 5.31 | <0.0001 |
| Sla | src-like adaptor | 5.30 | <0.0001 |
| Nfkbid | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta | 5.15 | 0.0044 |
| RGD1309870 | unknown function | 5.02 | 0.0005 |
| Tlr13 | toll-like receptor 13 | 4.93 | 0.0036 |
| Rabgef1 | Rab guanine nucleotide exchange factor (GEF) 1 | 4.66 | 0.0023 |
| Il9 | Interleukin-9 | 4.56 | 0.0039 |
| Zswim4 | zinc finger SWIM-type containing 4 | 4.20 | 0.0008 |
| Tnf | TNF-α | 3.83 | 0.0007 |
Fold change represents the expression level (Mincle-stimulated PA-11 cells/unstimulated PA-11 cells, n = 2/group) obtained from Microarray analysis. Unpaired two-tailed Student’s t-test was used to generate P value.