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. 2017 Apr 10;7:46258. doi: 10.1038/srep46258

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(a) Changes in contents of main substrates and products, based on metabolomic measurements. (b) Transcription levels of the main rate-limiting enzyme-encoding genes. (c) Activities of the main rate-limiting enzymes. (d) Main affected glucose metabolic pathways. Per-KD, BmPer knockdown BmN cells; WT, wild-type BmN cells; HK, hexokinase; PFK, phosphofructokinase; PK, pyruvate kinase; CS, citrate synthase; +, increased enzymatic activity; −, decreased content or enzyme activity, or down-regulated transcription of coding gene. *p ≤ 0.05 and **p ≤ 0.01.