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. 2017 Apr 1;34(7):1291–1301. doi: 10.1089/neu.2016.4628

FIG. 4.

FIG. 4.

(A) Effect of injury on non-synaptic and synaptic mitochondria for respiratory control ratio (RCR) (state III/state IV) 24 h after severe controlled cortical impact (CCI). (B) Effect of early post-injury (15 min) intraperitoneal administration of cyclosporine A (CsA) (20 mg/kg), on non-synaptic and synaptic mitochondria for RCR (state III/state IV) 24 h after severe CCI, calculated as % sham. Sham NS, sham non-synaptic (n = 6); Sham Syn, sham synaptic (n = 6); CCI + Veh NS, CCI + vehicle non-synaptic (n = 6); CCI + Veh Syn, CCI + vehicle synaptic (n = 6); CCI + CsA NS, CCI + CsA non-synaptic (n = 8); CCI + CsA Syn, CCI + CsA synaptic (n = 8); values = mean ± standard deviation; two-way analysis of variance followed by Tukey post hoc; *p < 0.05, **p < 0.001, #p < 0.05 vs non-synaptic vehicle, ##p < 0.01 vs. non-synaptic vehicle.