Fig. 3.

B-PLS results. A) The singular image at a bootstrap ratio threshold = ± 3.5, p < 0.001 and the brain-behavior correlation profile with 95% confidence intervals for B-PLS LV1. In the singular image red brain regions reflect positive brain saliences and blue regions reflect negative brain saliences. Activations are presented on template images of the lateral and medial surfaces of the left and right hemispheres of the brain using Caret software. The correlation profile indicates that encoding activity in positive salience regions was positively correlated with subsequent retrieval for both task in MA_{+ FH + APOE4} and MA_controls; and retrieval activity in these same regions was negative correlated with retrieval accuracy on both tasks in MA_{+ FH + APOE4}. In MA_+ FH encoding and retrieval activity in positive salience regions during SE tasks was correlated with better performance on this task. Negative salience regions exhibited the inverse pattern of brain-behavior correlations. B) The singular image at a bootstrap ratio threshold = ± 3.5, p < 0.001 and the brain-behavior correlation profile with 95% confidence intervals for B-PLS LV2. The correlation profile indicates that increased encoding and retrieval activity in positive salience regions was positively correlated with memory performance on both tasks in MA_{+ FH + APOE4} subjects, and negatively correlated with memory performance on both tasks in MA_+ FH. Negative salience regions exhibited the inverse pattern of brain-behavior correlations.