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. 2017 Jan 31;27(4):483–504. doi: 10.1038/cr.2017.18

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Copyright © 2017 Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences

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TTALE-based imaging of NOR-rDNAs. (A) Schematic diagram showing distribution and structural features of NOR-rDNAs in the human genome. (B) Co-localization analysis of mCherry-TTALE^rDNA (red) and EGFP-Rev (green, labeling nucleolus) signals captured by SIM-TEM. Arrowhead indicates mCherry-TTALE^rDNA signals at perinucleolar regions. Arrow indicates the fiducial marker (blue) for precise alignment of SIM and TEM images. Scale bars, 2 μm. (C) Live cell co-localization analysis of mCherry-TTALE^rDNA (red) and EGFP-Rev (green) in the indicated cell types. Dashed lines indicate the nuclear boundary. Scale bars, 5 μm. (D) Visualization of rDNA at different stages of mitosis in HeLa cells using mCherry-TTALE^rDNA (red). Hoechst was used to stain DNA (blue). Scale bars, 5 μm.