Figure 5.

Inhibition of NO-mediated phosphorylation of ERK and the expression of Slug by cordycepin (A) Effect of cordycepin on NO-mediated ERK phosphorylation and (B) relative band intensities of p-ERK/ERK. Each column represents the mean ± SD of three independent experiments. ***P < 0.001. (C) Inhibitory effect of L-NAME on ERK and Slug expression, and (D) relative band intensities of p-ERK/ERK and Slug in a concentration-dependent manner as reflected from the intensity of bands compared to non-L-NAME-treated controls. (E) Migration assay of A549 cells. Cells treated with L-NAME or their combinations with other agents exhibited an extremely significant inhibition of cell migration compared with control cells. Data are expressed as means ± SD, ***P < 0.001.