Figure 1.

Chk1 ablation can significantly suppress the cell proliferation and sensitize the IR treatment in gastric cancer cells. A, B. Graphical presentation of cell viability at different days examined by MTS assay after Chk1 knockdown. OD values were measured and plotted with respect to time (*P<0.05). C. Graphical presentation of relative (%) cell viability of AGS and MKN1 cells exposed with IR (2 Gy), and with IR (4 Gy) respectively, (*P<0.05). D. Western blot analyses using anti-Chk1 antibodies showing Chk1 siRNA efficiently inhibited the expression of Chk1 in AGS and MKN1 cells. Actin was used as a loading control.