Table 5.
Analysis on ARID1A immunohistochemistry status in the ampullary tumors group
| Characteristics | ARID1A loss or weak staining (n=10) | ARID1A positive staining (n=48) | p-valuea |
|---|---|---|---|
| Age at surgery (yrs), median [range] | 54.0 [38.0-71.0] | 67.5 [41.0-79.0] | 0.04 |
| Gender (n, %) | |||
| Female | 6 (60.0%) | 19 (39.6%) | 0.30 |
| Male | 4 (40.0%) | 29 (60.4%) | |
| Differentiation degree (n, %) | 0.29 | ||
| G1, G1-G2 | 2 (20.0%) | 11 (22.9%) | |
| G2, G2-G3 | 5 (50.0%) | 30 (62.5%) | |
| G3 | 3 (30.0%) | 5 (10.4%) | |
| Unknownb | 0 (0.0%) | 2 (4.2%) | |
| pN (n, %) | 0.29 | ||
| N0 | 5 (50.0%) | 33 (68.75%) | |
| N1 | 5 (50.0%) | 15 (31.25%) | |
| pT (n, %) | 0.87 | ||
| T1 | 1 (10.0%) | 7 (14.6%) | |
| T2 | 5 (50.0%) | 19 (39.6%) | |
| T3 | 3 (30.0%) | 19 (39.6%) | |
| T4 | 1 (10.0%) | 3 (6.3%) | |
| Tumor size (cm), median [range] | 2.5 [1.0-3.0] | 2.0 [0.4-10.0] | 0.57 |
| Status (n, %) | |||
| Alive | 5 (50.0%) | 27 (56.2%) | 1.0 |
| Dead | 4 (40.0%) | 21 (43.8%) | |
| Unknownb | 1 (10.0%) | 0 (0.0%) | |
| Overall survival (months), median [range] | 39.2 [1.64-127.9] | 24.9 [0.39-160.3] | 0.37 |
| ARID1A IHC subtype (n, %) | |||
| Pancreatobilliary | 3 (30.0%) | 21 (43.8%) | 0.59 |
| Intestinal | 5 (50.0%) | 18 (35.7%) | |
| Ambigous | 1 (10.0%) | 9 (18.8%) | |
| Unknownb | 1 (10.0) | 0 (0.0%) |
a
differences between age and tumor sizes were calculated by means of Mann-Whitney test; differences in overall survival were calculated by means of Log-Rank Mantel Cox test; the rest were tested by Fisher exact t-test or Chi-square test;
b
not included in p-value calculation.