Downregulation of ACSM3 is correlated with poor prognosis in HCC patients. A: Representative photomicrographs showed strong (+++), moderate (++), weak (+), or negative (-) staining of ACSM3 in HCC specimens (magnification, ×100, ×400). B: Kaplan-Meier analysis of overall survival and time to recurrence in 235 HCC patients based on ACSM3 expression.