Table 2.
Univariate and multivariate analyses of prognostic variables
| OS | OS | PFS | PFS | |||||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |||||
|
| ||||||||
| Variable | P value | P value | HR | 95% CI | P value | P value | HR | 95% CI |
| Gender (Female VS. Male) | 0.792 | 0.751 | 1.086 | 0.652-1.811 | 0.971 | 0.901 | 1.030 | 0.647-1.638 |
| Age (<65 vs. ≥65) | 0.760 | 0.483 | 0.828 | 0.489-1.403 | 0.908 | 0.638 | 0.892 | 0.554-1.436 |
| Smoking (Yes vs. No) | 0.765 | 0.138 | 1.624 | 0.855-3.084 | 0.835 | 0.213 | 1.457 | 0.806-2.635 |
| Drinking (Yes vs. No) | 0.671 | 0.200 | 1.555 | 0.792-3.051 | 0.460 | 0.083 | 1.735 | 0.931-3.236 |
| T stage | 0.001* | 0.016* | <0.001* | 0.008* | ||||
| T1 | 1.000 | Ref. | 1.000 | Ref. | ||||
| T2 | 0.026* | 3.207 | 1.148-8.958 | 0.028* | 2.798 | 1.118-7.003 | ||
| T3 | 0.002* | 5.075 | 1.845-13.96 | 0.001* | 4.701 | 1.971-11.53 | ||
| T4 | 0.062 | 2.638 | 0.951-7.314 | 0.045* | 2.533 | 1.022-6.278 | ||
| N stage | <0.001* | <0.001* | <0.001* | <0.001* | ||||
| N0 | 1.000 | Ref. | 1.000 | Ref. | ||||
| N1 | 0.002* | 3.108 | 1.531-6.312 | <0.001* | 3.542 | 1.847-6.793 | ||
| N2 | 0.004* | 2.804 | 1.383-5.686 | 0.009* | 2.392 | 1.241-4.610 | ||
| N3 | <0.001* | 6.988 | 3.004-16.26 | <0.001* | 6.771 | 3.069-14.94 | ||
| Differentiation | 0.020* | 0.272 | 0.140 | 0.447 | ||||
| Well | 1.000 | Ref. | 1.000 | Ref. | ||||
| Moderate | 0.107 | 1.713 | 0.890-3.296 | 0.275 | 1.393 | 0.768-2.527 | ||
| Poor | 0.475 | 1.253 | 0.675-2.325 | 0.907 | 0.967 | 0.548-1.704 | ||
| Adjuvant therapy (Yes vs. No) | 0.034* | 0.002 | 2.301 | 1.368-3.870 | 0.012* | <0.001* | 2.577 | 1.584-4.192 |
| IDH2 | 0.003* | <0.001* | 3.107 | 1.735-5.565 | 0.002* | <0.001* | 3.473 | 2.040-5.912 |
| (Overexpression VS. nonoverexpression) | ||||||||
Abbreviations: OS, overall survival; PFS, progression-free survival; CI: confidence interval.
*
P<0.05.