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. 2017 Mar 1;7(3):727–739.

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Effects of obesity and S3I-201 on lobulo-alveolar development and morphology of the mammary glands of wild type (WT) and Thrb^PV/PVPten^+/- mice. (A) Histopathology of mammary glands of WT and Thrb^PV/PVPten^+/- mice fed with low fat diet (LFD) or high fat diet (HFD), and treated with vehicle or S3I-201. The histopathological changes were given a score based on the rating scale in (a). The distribution of scores is shown in (b). The genotypes of mice are as marked. (B) Effects of S3I-201 on obesity-induced aberrant lobulo-alveolar development in HFD-Thrb^PV/PVPten^+/- mice. Hematoxylin and eosin-stained sections of mouse mammary tissue from LFD-WT with/without S3I-201 (a, b) and HFD-WT with or without S3I-201 (e and f), and a LFD-Thrb^PV/PVPten^+/- with/without S3I-201 (c and d) and HFD-Thrb^PV/PVPten^+/- with/without S3I-201 (g and h) mice.