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Effects of HFD and S3I-201 on the serum levels of TSH, thyroid hormones, and estrogens in WT and ThrbPV/PVPten+/- mice. (A) Thyroid function tests of WT and ThrbPV/PVPten+/- mice fed with LFD or HFD and treated with vehicle or with S3I-201. Levels of TSH (Aa, n = 7-11), total T4 (Ab, n = 7-18), total T3 (Ac, n = 7-12) were determined as described in Methods and Materials. The genotypes are marked. (B) E2 was determined as described in Methods and Materials (n = 6-12).
