FIG. 1.
Sequences of the N-terminal ZBDs associated with the arterivirus EAV nsp10 and coronavirus HCoV-229E nsp13 helicases. Amino acid residues are numbered according to their positions in the pp1ab replicase polyproteins of EAV and HCoV-229E, respectively. 3C-like protease cleavage sites that flank the EAV and HCoV-229E helicases in pp1ab are given, and the hinge spacer region of nsp10 (residues Glu2427 to Pro2430) is underlined. Also indicated are the amino acid substitutions characterized in this study.