TABLE 1.

Crystallographic data and refinement statistics

Data set (space group)	P212121
Molecules per asymmetric unit	2
Cell edges a, b, c (Å)	52.9, 68.6, 270.2
Resolution range (Å)	20-3.6
% Completenessa	92 (81)
I/σ(I)a	12.3 (2.6)
Rmerge (%)a	12.0 (53.8)
Unique reflections	12,090
Rcrystb	0.279
Rfreec	0.324
Avg B factor (Å2)
Protein (chains A and B)	73.6, 74.1
Water molecules	41.7
Rmsdd bond length (Å)	0.009
Rmsd bond angle (°)	1.532
Rmsd bonded B factor (Å2)
Main chain	2.65
Side chain	3.45
Ramachandran plot (%)
Favored	71.1
Allowed	28.2
Generous	0.7
Disallowed	0

^aNumbers in parentheses are for the highest-resolution shell, 3.73 to 3.60 Å.

^bR_cryst, Σ_hkl‖F_obs| − |〈F_calc〉‖/Σ_hkl|F_obs|.

^cR_free, R_cryst with 5% of F_obs sequestered before refinement.

^dRmsd, root mean square difference.