Figure 3. Negative feedback loop involving TP53 and AKT1: In presence of AKT1, TP53 is silenced by MDM2, whereas TP53 in its presence represses AKT1 via PHLDA3.
AKT1 in turn is upregulated by IRF6 in HNSCC.
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.