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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Virology. 2017 Feb 23;505:113–126. doi: 10.1016/j.virol.2017.02.015

Fig. 6. Detailed analyses of 9F6 maturation.

Fig. 6

(A) Sequence variation of the HCDRs of the 9F6 clonal family. The germline sequence is shown at the top. The 9F6 sequence is shown at the bottom, with mutated residues indicated in red. (B) Lineage tree derived from representative sequences from the sample, selected to illustrate the inferred development of the antibody. Amino acid changes as a result of a possible gene conversion event are highlighted in blue. (C) Sequence identity/divergence plot of heavy chain sequences sharing the 9F6 germline. Clones shown in panel B are indicated, with inferred intermediates marked in red. The intermediates indicate good coverage of the development history. The contour plot encompasses all full-length productive sequences of the IGHV1S40 germline extracted from PBMC samples. The inferred 9F6 germline is marked by a blue cross.