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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Virology. 2017 Feb 23;505:113–126. doi: 10.1016/j.virol.2017.02.015

Fig. 7. Hypothetical comparison of two vaccine strategies.

Fig. 7

(A) A homologous prime-boost vaccine strategy using a whole, trimeric gp120/gp41 complex. Because MPER neutralizing epitopes (indicated by asterisks) are immunorecessive, B cells that target them are not stimulated sufficiently and are eventually eliminated. (B) In addition to sequential immunization with different immunogens (heterologous prime-boost), the unique and a novel feature of the IPAS-RAM vaccine strategy is co-immunization in a phased manner, which we expect will allow selective amplification of antibodies against common epitopes through immunological crosstalk and concurrent boosting. It is hypothesized that this could potentially rescue B cells against immunorecessive neutralizing epitopes.