FIG. 3.

The Koz1 virus replicates to high titers in the pancreata and hearts of BALB/c mice. Twelve BALB/c mice were infected with 5,000 PFU of the P1 stock of Koz1 virus (sequence CAUAUGG). Three mice died by 2 days postinfection; the hearts and pancreata of the remaining nine mice were harvested at 2, 5, or 9 days postinfection, and virus titers were determined. For each time point and in each tissue the means are shown, along with the standard deviation. As described in the text, RNA was isolated from all 18 organs, and sequence analyses of numerous clones from each showed that the Koz1 sequence remained stable in vivo, even as late as 9 days postinfection.